Study compares clinical features of COVID-19 and seasonal influenza in children

As the slide strategies, pediatric hospitals will commence viewing little ones with seasonal influenza A and B. At the very same time, COVID-19 will be co-circulating in communities with the flu and other respiratory viruses, building it a lot more tricky to determine and protect against the novel coronavirus.

With small revealed facts specifically evaluating the medical attributes of little ones with COVID-19 to all those with seasonal flu, scientists at Kid’s Nationwide Medical center resolved to perform a retrospective cohort analyze of people in the two teams. Their results — revealed September eight in JAMA Community Open up — shocked them.

The analyze — in-depth in the post “Comparison of Medical Capabilities of US Youngsters With COVID-19 vs Seasonal Influenza A and B” — confirmed no statistically important variances in the fees of hospitalization, admission to the intense treatment device and mechanical ventilator use involving the two teams.

The other unpredicted getting was that a lot more people with COVID-19 than all those with seasonal influenza documented fever, cough, diarrhea or vomiting, headache, overall body ache or upper body suffering at the time of analysis, claims Xiaoyan Tune, Ph.D., M.Sc., M.B., the study’s principal investigator.

“I failed to see this coming when I was wondering about accomplishing the analyze,” claims Dr. Tune, director of An infection Management and Epidemiology at Kid’s Nationwide considering the fact that 2007 and a professor of pediatrics at the George Washington College College of Drugs and Wellness Sciences. “It took quite a few rounds of wondering and combing via the facts to persuade myself that this was the summary.”

Supplied that a lot stays unidentified about COVID-19, the researchers’ discovery that little ones with the sickness existing with a lot more signs at the time of analysis is a beneficial a single.

It is a fantastic cue from a avoidance and setting up standpoint. We usually emphasize early recognition and early isolation with COVID. Obtaining a medical image in head will help clinicians as they diagnose people with signs of the coronavirus.”

Dr. Xiaoyan Tune, Ph.D., M.Sc., M.B., study’s principal investigator

The analyze incorporated 315 little ones who have been identified with a laboratory-verified COVID-19 involving March 25, 2020, and Might 15, 2020, and one,402 little ones who have been identified with a laboratory-verified seasonal influenza involving Oct. one, 2019, and June six, 2020, at Kid’s Nationwide. Asymptomatic people who examined beneficial for COVID-19 throughout pre-admission or pre-procedural screening have been excluded from the analyze.

Of the 315 people who examined beneficial for COVID-19, 52% have been male, with a median age of eight.four several years. Of these people, 54 (17.one %) have been hospitalized, together with 18 (five.seven%) who have been admitted to the intense treatment device (ICU) and 10 (three.two%) who gained mechanical ventilator therapy.

Among the the one,402 people who examined beneficial for influenza A or B, 52% have been male, with a median age of three.nine several years, and 291 (21.two%) have been hospitalized, together with 143 for influenza A and 148 for influenza B. Ninety-8 people (seven.%) have been admitted to the ICU, and 27 (one.nine%) gained mechanical ventilator aid.

The analyze confirmed a slight variation in the age of little ones hospitalized with COVID-19 in contrast to all those hospitalized with seasonal influenza. Clients hospitalized with COVID-19 experienced a median age of nine.seven several years vs. all those hospitalized with seasonal influenza who experienced a median age of four.two several years.

In equally teams, fever was the most normally documented symptom at the time of analysis adopted by cough. A better proportion of people hospitalized with COVID-19 than all those hospitalized with seasonal influenza documented fever (76% vs. 55%), cough (48% vs. 31%), diarrhea or vomiting (26% vs. 12%), headache (11% vs. three%), overall body ache/myalgia (22% vs. seven%), and upper body suffering (11% vs. three%).

Additional people hospitalized with COVID-19 than all those with seasonal influenza documented sore throat or congestion (22% vs. 20%) and shortness of breath (30% vs. 20%), but the variances have been not statistically important.

For the duration of the analyze time period, the scientists observed an abrupt decrease of influenza circumstances at Kid’s Nationwide just after neighborhood universities shut in mid-March and keep-at-dwelling orders have been executed about two months later on to beat the local community distribute of COVID-19. Dr. Tune claims the affect of university closures on the distribute of COVID-19 amongst little ones is the future place of analyze for her analysis workforce.

“We want to evaluate the quantitative affect of university closures so we can ascertain at what place the value of closing universities and remaining at dwelling outweighs the gain of cutting down transmission of COVID-19 and burdens on the health and fitness treatment procedure,” she claims.

Dr. Tune urges customers of the local community “1st and foremost to keep tranquil and be powerful. We are mastering new and beneficial matters about this virus just about every working day, which in switch enhances treatment. The collision of the flu and COVID-19 this slide could signify an raise in pediatric hospitalizations. That is why it really is essential to get your flu shot, since it can assistance choose at the very least a single respiratory virus out of circulation.”

Journal reference:

Tune, X., et al. (2020) Comparison of Medical Capabilities of COVID-19 vs Seasonal Influenza A and B in US Youngsters. JAMA Community Open up. doi.org/10.1001/jamanetworkopen.2020.20495.

Children's Health

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